The purpose of this essay was to review the literature and describe the patophysiology, diagnosis, microscopic and macroscopic appearance of aortic body tumors in dogs. The tumors originate from the chemoreceptor organs situated at the base of the heart. The chemoreceptor organs are neuroendocrine cells responsible for surveillance of changes in e.g. the blood pH. Aortic body tumors are rare and represent 7 % of the total cases of primary cardiac tumors in canines.

Mast cells have for a long time been known to accumulate around tumors (Maltby et al., 2009). Studies show that they may be important and sometimes essential in tumor angiogenesis, tumor growth and metastasis of tumors (Soucek, et al., 2007; Xiang et al., 2010). In an expression array study (Wensman et al, submitted manuscript) performed on mouse mast cells exposed to tumor conditioned medium, the gene 4-1BB was among the most up-regulated genes compared to control medium. 4-1BB codes for a membrane receptor protein of the tumor necrosis factor superfamily and has been shown to be important in T cell regulation in tumor diseases. This study was performed to investigate if human mast cells up-regulate 4-1BB when they get exposed to tumor conditioned medium.

Mammary tumors are the most frequent type of tumors in bitches in Sweden. Many studies have been published concerning mammary tumors, but there is still much to be learned about this disease. One has, since some time ago, had the knowledge that addition to or removal of methyl groups to genes can inhibit or activate gene-expression. Methylation and demethylation is a normal phenomenon in the body and it is essential for the development and survival of the individual. The risk of developing a tumor disease is increased if the global methylationstatus is changed; if oncogenes demethylates (activates) or if tumor suppressor genes methylates (inactivates). In the human medicine one has seen that there are differences in methylationstatus between different tumors. In this study tumor and normal tissue from ten dogs were examined with regard to methylationstatus.

It?s been noted that cows held at the section of ruminant medicine and epidemiology, Swedish University of Agricultural Sciences (IME), used for the education of veterinary students, have a lower heart rate than what is considered normal for ruminants. In this investigation the heart rates of seven lactating cows were recorded continuously during the period around drying off. The first recording took place at the farm from where the cows were bought, and then their heart rate was monitored after their arrival at IME and further on until they were completely dried off. The results were then compared to the heart rate of seven already dried off cows from the same farm.

Heart failure is the most common reason to hospitalization among persons over 65 years old. Self-care is an important part in the treatment of heart failure, but poor information and knowledge limits the ability of self-care and increases the risk of admission to hospital.The aim of the study was to investigate what information patients with heart failure describes that they receive from health care personal, how information is perceived, who provides the information, and on what occasions it is given. The aim was also to investigate whether patients' perception of knowledge about heart failure increased after hospitalization.The study is cross-sectional study with a descriptive design. A consecutive selection was used. A questionnaire was filled in by 28 participants.The study has shown that patients with heart failure largely experience information about heart failure inadequate.

Ej tillgänglig fram till 29 juli 2015.

Background:For patients with severe heart disease, may heart transplantation be the only opportunity for survival. Previous research highlights the importance of the nurse's role as supporters and knowledge brokers. People who has undergone heart transplant may be changed forever. Having to undergo a heart transplant can lead to that patients end up in a traumatic crisis. People's perception of herself and her perception of the world is also changing when the body is injured or suffers a disease.

AbstractThis report aims, through interviews, observations and literature review to examine what some of the youngest children know about the heart, blood and bloodstream. The sample size was twenty children, half of them are at the age of three and the other half is at the age of six.The interviews showed that children at the age of six had better knowledge than children at the age of three, but one child knew that we have the blood corpuscle in the body. He was also the only one who mentioned the blood corpuscle of all children who participated in the research. Children at the age of three could not see the functional relationship between the blood and heart. One child who was six years told that the air we breathe goes directly in the heart from where the blood is circulating to the rest of the body, together with the food.Keywords: heart, blood, bloodstream, the body.

The RECK gene is a relatively new discovered gene with important implications for cancer research. The research has been primarily concentrated on the human gene with the ultimate aim to identify the invasive characteristics. Up regulated RECK is linked to significantly prolonged survival rates in patients with severe forms of malignancies. RECK is normally expressed in all cells of the body and has an important role in the balance between destructive and constructive features of the extracellular matrix. The RECK protein is a membrane-bound glycoprotein that inhibit matrix metalloproteinases which has the function of breaking down the ECM. There is a significant correlation between RECK gene expression and the formation of new vessels, presumably via the mediation of VEGF which is an important and powerful inducer of angiogenesis.

The aim of the study was to describe how women and men with diagnosed heart disease experience their health-related quality of life and what differences there is between genders in their quality of life and also describe problems after receiving the diagnosis. The study also aimed to describe rehabilitation of patients with heart disease. The study was a descriptive literature study based on scientific articles. It emerged that both women and men with heart disease experienced lower quality of life compared to normative data. There was a significant difference between women and men both one year and three years after receiving the diagnosis heart disease, which showed that women experienced lower quality of life than men.

This student report is a literature study about cardiac insufficiency in cats and it is written mainly for veterinary nurses. It is about cats with an underlying heart disease that has led to an incompensated heart failure.It presents a general basis on normal anatomy and physiology, and also how to make the diagnosis, therapy and intensive care.The student report is also about the role of the veterinary nurse during the process of the disease, how to help the veterinarian in the best way, how to handle anesthesia in cats with a heart disease, which factors that can have a significant matter in feeding, and what advices to give to a pet owner with a cat with a incompensated heart failure..

The aim: To examinate depressive symptoms among heart failure patients. Another aim was to examinate the differences in depressive symptoms between gender and between heart failure patients and the population. METHOD: The self-assassment formula MADRS was answered by twenty patients with heart failure at the University hospital in Uppsala. MAIN RESULT: Among the participants 31,3 % showed diffrent levels of depressive symptoms. Mild depression was more common in women.

Catecholamines are stress hormones that are produced and released by a rare tumor called pheochromocytoma. This tumor can cause hypertension which if undiagnosed and untreated leads to death. Since good therapy is available, it is important to find the tumor in time. The most common way to diagnose the tumor is measurement of the biochemical markers; catecholamines and their metabolites, methylated catecholamines.After observation that almost all normetanephrine results for women were higher than the upper reference limit and therefore pathological, the accuracy of the present reference intervals was questioned. Therefore new reference intervals for both urinary catecholamines and methylated catecholamines were developed by analysis of 46 samples using HPLC.

Background: Patients with heart failure is a patient group growing in numbers, the most common treatment focuses on reliving symptoms and the only cure is heart transplantation. Objective: Aim of the study was to illuminate patients' experiences of living with heart failure at his home. Method: Qualitative design, with a manifest content analysis. The results are based on 12 scientific articles.  Results: Patients with heart failure find that the disease is limited to their daily lives through mental illness and physical symptoms.

Background: Coronary heart disease kills more than 7 million people worldwide each year. High levels of blood fat, cholesterol, contributes significantly to coronary heart disease. Lifestyle changes combined with lipid-lowering drugs, statins, is an effective treatment. But adherence to statins is low, not even a myocardial infarction always contributes to adherence. Adherence requires patient education and good communication between patient and physician.